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Institute of Physiology of the Czech Academy of Sciences / BIOCEV
Biotechnology and Biomedicine

Institute of Physiology of the Czech Academy of Sciences / BIOCEV

General description


IPHY is leading research institution in the field of normal and pathological physiology (located in the BIOCEV). The main activity of IPHYS is scientific research in physiology, namely in the study of molecular, cellular and systemic mechanisms of physiological functions and in the fields of neurophysiology and cardiovascular physiology. IPHYS is a holder of the European HR Excellence in Research Award.

Key Research Facilities, Infrastructure and Equipment

  • Equipment for expression of recombinant proteins in E. coli (orbital shakers, centrifuges, sonicators, autoclaves, coldrooms, fridges and freezers)
  • DNA manipulations and engineering of expression construcuts
  • Protein purification (FPLC systems with columns for affinity, ionexchange, hydrophobic and size-exclusion chromatography
  • X-ray crystallography (crystallization robot ArtRobbins Gryphon dropsetter, Formulatrix RI 1000 crystallisation hotel, Bruker D8 Venture diffractometer)
  • Electron microscopy for preliminary sample screening (Jeol JEM 2100), mass spectrometry for HDX and crosslinking experiments (Bruker Daltonics 15TSolarix XR FT-ICR mass spectrometer)
  • Genomic core for semi high throughput DNA isolation
  • Cryo-electron microscopes with capacity of high-resolution data collection
  • UV-VIS spectrophotometers, steady-state fluorescence spectrophotometer, DLS and a real-time PCR LightCycler 480 II (Roche Applied Science) for the protein stability measurements using DSF


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Contact person

Contact us to know more about our location and work environment. Please use the main contact for questions related to administrative matters. Please contact the supervisors/group leaders of respective research groups regarding feasibility of your research proposal with regard to the research group activities.

Your future supervisors

Research groups

The following research groups of this Hosting organisation are involved in the first call of MERIT. The candidates can freely formulate their own research topic aligned with activities and research focus of these research groups.

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2 calls
30 fellowships
30 months