The laboratory of Medicinal Chemistry of Charles University is located in BIOCEV center. The laboratory focuses on the molecular design, synthesis, separation, characterization and bioanalytical testing of medicinally active organic compounds and their formulations. In terms of medical applications, we focus on theranostics, cellular testing, enzymatic, epigenetic and pharmaceuticals. The molecular design is based on organic compounds based on structural motifs such as hydrazones, methine salts, coumarins, curcumins or Tröger bases. The medicinal potential of the prepared molecules is tested independently or in collaboration with excellent colleagues from the Czech Republic and abroad.
Key Research Facilities, Infrastructure and Equipment
- NMR Spinsolve (ULTRA 80MHz, Magritec) with 20x sample feeder and flow-through reaction monitoring system. The system allows measurements without deuterated solvent.
- UV/VIS spectrophotometer SHIMADZU UV-2401
- Spectrofluorimeter (RF-6000, Shimadzu)
- Microplate UV/VIS reader SpecraMax®
- Liquid chromatograph (U)HPLC-SPD/RF/MS (Nexera Shimadzu)
- Flash/Pure chromatograph
- Emax High Energy Ball Mill (Retsch)
- Cryogenic Mill (RETCH)
- LabScale Reactor 4 L
- Infrared spectrometer (IRSpirit, Shimadzu)
- Laser particle size diffraction analyzer (SALD-2300, Shimadzu)
Contact us to know more about our location and work environment. Please use the main contact for questions related to administrative matters. Please contact the supervisors/group leaders of respective research groups regarding feasibility of your research proposal with regard to the research group activities.
Petr SolilHead of Communications
Your future supervisors
I am the head of the Laboratory of Medicinal Chemistry, which focuses on the molecular design, synthesis, separation, characterization and bioanalytical testing of medicinally active organic compounds and their formulations. In terms of medical applications, we focus on theranostics, cellular testing, enzymatic, epigenetic and pharmaceuticals. The molecular design is based on organic compounds based on structural motifs such as hydrazones, methinium salts, coumarins, curcumins or Tröger bases. The medicinal potential of the prepared molecules is tested independently or in collaboration with excellent colleagues from the Czech Republic and abroad.
The successful applicant will work in the Medicinal Chemistry group of the 1st Faculty of Medicine of Charles University in the BIOCEV Center.
The postdoctoral fellow will join the research team in the Medicinal Chemistry pipeline, which is focused on innovative research and development of new drugs based on small molecules and which works to find solutions to various problems in the area of preclinical testing. The key research infrastructure and equipment of this research group include an in silico computing infrastructure, an organic laboratory, a tissue laboratory and a formulation laboratory with the main selected instruments such as NMR, nanomills or an automatic peptide synthesizer.
This fellow may also connect with international collaborators, e.g. within our Horizon cooperative project, own core facilities at the BIOCEV center through international collaborations or have the opportunity to undertake a temporary assignment in the non-academic sector in collaboration with our industrial partners, across biotechnologies e.g. Essence Line, Santiago Chemicals or C2P.
Due to the main focus of our research group, the expected outputs of the scholarship are high-quality scientific publications / outputs of applied research, such as patent applications, market validation, new collaborations with industry, joint research projects within the framework of supranational grant agencies or international projects at the Horizon level.
Potential areas of knowledge of applicants that may be suitable for our research group: Education in the field of biology or biochemistry or medicine, Experience with experimental techniques including testing new substances based on small molecules: toxicity, bioavailability, bioactivity, migrastatics or theranostics, Experience with the creation of professional literature, or publication activity in impact periodicals, foreign experience of at least one year.
It would be good to have additional knowledge or experience of the applicant. Example: programming languages, statistical methods used in life sciences, etc.
Personal qualities are good to have: work and think independently with a proactive approach, with a tendency to build a team and solve problems, coordinate and lead your colleagues within a subgroup, independent creation of professional outputs.